Guus Brand A couple of weeks ago, the decentral selection process ended in all medical faculties in the Netherlands. This is a process that I have passed through six years ago myself when I applied for medical school at Radboud University. Thousands of middle school teens apply and join in the selection process, but only 20-25 percent of them actually succeed in entering medical school. The selection is often described as difficult and stressful. So difficult that there is a booming business … [Lees meer...]
Extrachromosomal DNA at the carcinogenesis wheel: driving cancer through genomic instability?
Aster Witvliet If you have ever seen an image of the chromosomes (also known as a karyotype) inside a cancer cell, you know that their genetic material can get mixed around to end up looking like a child’s arts and crafts project. A part of chromosome 3 might suddenly be fused to chromosome 14, or chromosome 4 might have acquired a piece of chromosome 5 in the middle. One of the hallmarks of cancer is genomic instability, meaning that cancer cells accumulate DNA mutations and other defects … [Lees meer...]
A vaccine for malaria
Minke Holwerda, BSc Biomedical Sciences This October, the Director-General Dr Tedros Adhanom Ghebreyesus of the World Health Organization (WHO) called it a ‘historic moment’, when the WHO officially recommended the use of the first vaccine against malaria in children living in sub-Saharan Africa [1]. Malaria is a disease caused by Plasmodium parasites that are transmitted to humans by Anopheles mosquitoes and is one of the leading causes of death in low-income countries [2, 3]. In … [Lees meer...]
Lessons from the past
Bloodletting on prescription Yfke Prins, BSc Medicine Much to my surprise, an internist mentioned that the treatment of choice for a patient with polycythemia vera (PV) was bloodletting. I thought I had misunderstood her for a second, but then she repeated her sentence, probably after seeing my puzzled face. She was serious, and, as I discovered that day, bloodletting (also known as phlebotomy) is still applied in the clinic; although, much less frequent than, e.g. during the Middle Ages. … [Lees meer...]
The power of plants: a cure for COVID-19?
Minke Holwerda, BSc Biomedical Sciences Unless you have been living under a rock, it has probably not escaped you that we are currently in the midst of a worldwide pandemic, caused by severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). While vaccines are being developed, produced, and injected in a (more or less) high tempo, a cure for coronavirus disease 2019 (COVID-19) has not yet been found. In the race for the COVID-19 cure, some countries have turned to exploring the … [Lees meer...]
Get rid of that late night snack! – The relation between timing of food intake and weight gain
Quentin Marsman, BSc Medicine Late-night eating is an activity we all participate in once in a while. We all enjoy that snack right before bed after an evening with intense exercise or a hamburger after going to the bar. Nevertheless, these snacks could be more detrimental to our health than we might think. Studies show that the timing of food intake has a relation to weight gain. Experimental studies in animals show that unusual feeding time leads to obesity, even in the absence of changes … [Lees meer...]
The use of long-acting antivirals in HIV treatment
Thomas Nieuwenstein, BSc Biomedical Sciences Human Immunodeficiency Virus (HIV) treatment has come a long way since the introduction of the first anti-HIV treatment – azidothymidine, or better known as zidovudine, a nucleoside reverse transcriptase inhibitor – in 1987 [1]. While the drug proved to be effective at reducing opportunistic infections and AIDS-related deaths, it caused severe adverse effects in the patient population [1]. Since then, new drugs have been developed which have turned … [Lees meer...]
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